Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.
Identifieur interne : 000835 ( Main/Exploration ); précédent : 000834; suivant : 000836Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.
Auteurs : Jorge Gandía [Espagne] ; Xavier Morat [Espagne] ; Igor Stagljar [Canada] ; Víctor Fernández-Due As [Espagne] ; Francisco Ciruela [Belgique]Source :
- Behavioural brain research [ 1872-7549 ] ; 2015.
English descriptors
- KwdEn :
- Adenosine A2 Receptor Antagonists (pharmacology), Animals, Jaw (drug effects), Jaw (physiopathology), Male, Mice, Inbred C57BL, Mice, Knockout, Movement (drug effects), Movement (physiology), Muscarinic Antagonists (pharmacology), Parkinsonian Disorders (drug therapy), Parkinsonian Disorders (physiopathology), Pilocarpine, Pyrimidines (pharmacology), Receptor, Adenosine A2A (metabolism), Receptors, G-Protein-Coupled (genetics), Receptors, G-Protein-Coupled (metabolism), Tremor (drug therapy), Tremor (physiopathology), Triazoles (pharmacology), Tropicamide (pharmacology).
- MESH :
- chemical , genetics : Receptors, G-Protein-Coupled.
- chemical , metabolism : Receptor, Adenosine A2A, Receptors, G-Protein-Coupled.
- chemical , pharmacology : Adenosine A2 Receptor Antagonists, Muscarinic Antagonists, Pyrimidines, Triazoles, Tropicamide.
- drug effects : Jaw, Movement.
- drug therapy : Parkinsonian Disorders, Tremor.
- physiology : Movement.
- physiopathology : Jaw, Parkinsonian Disorders, Tremor.
- Animals, Male, Mice, Inbred C57BL, Mice, Knockout, Pilocarpine.
Abstract
GPR37, also known as parkin associated endothelin-like receptor (Pael-R), is an orphan GPCR that aggregates intracellularly in a juvenile form of Parkinson's disease. However, little is known about the function of this orphan receptor. Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic. Interestingly, the control that adenosine A2A receptor exerted over TJMs was lost in the absence of GPR37, thus pointing to a pivotal role of this orphan receptor in the adenosinergic control of parkinsonian tremor.
DOI: 10.1016/j.bbr.2015.04.001
PubMed: 25862943
Affiliations:
- Belgique, Canada, Espagne
- Catalogne, Ontario, Province de Flandre-Orientale
- Barcelone, Gand, Toronto
- Université de Barcelone, Université de Toronto
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Electronic address: fciruela@ub.edu.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain; Department of Physiology, Faculty of Sciences, University of Ghent, 9000 Gent</wicri:regionArea><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author></analytic><series><title level="j">Behavioural brain research</title><idno type="eISSN">1872-7549</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine A2 Receptor Antagonists (pharmacology)</term><term>Animals</term><term>Jaw (drug effects)</term><term>Jaw (physiopathology)</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Movement (drug effects)</term><term>Movement (physiology)</term><term>Muscarinic Antagonists (pharmacology)</term><term>Parkinsonian Disorders (drug therapy)</term><term>Parkinsonian Disorders (physiopathology)</term><term>Pilocarpine</term><term>Pyrimidines (pharmacology)</term><term>Receptor, Adenosine A2A (metabolism)</term><term>Receptors, G-Protein-Coupled (genetics)</term><term>Receptors, G-Protein-Coupled (metabolism)</term><term>Tremor (drug therapy)</term><term>Tremor (physiopathology)</term><term>Triazoles (pharmacology)</term><term>Tropicamide (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptor, Adenosine A2A</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adenosine A2 Receptor Antagonists</term><term>Muscarinic Antagonists</term><term>Pyrimidines</term><term>Triazoles</term><term>Tropicamide</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Jaw</term><term>Movement</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinsonian Disorders</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Jaw</term><term>Parkinsonian Disorders</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Pilocarpine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">GPR37, also known as parkin associated endothelin-like receptor (Pael-R), is an orphan GPCR that aggregates intracellularly in a juvenile form of Parkinson's disease. However, little is known about the function of this orphan receptor. Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic. Interestingly, the control that adenosine A2A receptor exerted over TJMs was lost in the absence of GPR37, thus pointing to a pivotal role of this orphan receptor in the adenosinergic control of parkinsonian tremor.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Canada</li><li>Espagne</li></country><region><li>Catalogne</li><li>Ontario</li><li>Province de Flandre-Orientale</li></region><settlement><li>Barcelone</li><li>Gand</li><li>Toronto</li></settlement><orgName><li>Université de Barcelone</li><li>Université de Toronto</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Gandia, Jorge" sort="Gandia, Jorge" uniqKey="Gandia J" first="Jorge" last="Gandía">Jorge Gandía</name></region><name sortKey="Fernandez Due As, Victor" sort="Fernandez Due As, Victor" uniqKey="Fernandez Due As V" first="Víctor" last="Fernández-Due As">Víctor Fernández-Due As</name><name sortKey="Morat, Xavier" sort="Morat, Xavier" uniqKey="Morat X" first="Xavier" last="Morat">Xavier Morat</name></country><country name="Canada"><region name="Ontario"><name sortKey="Stagljar, Igor" sort="Stagljar, Igor" uniqKey="Stagljar I" first="Igor" last="Stagljar">Igor Stagljar</name></region></country><country name="Belgique"><region name="Province de Flandre-Orientale"><name sortKey="Ciruela, Francisco" sort="Ciruela, Francisco" uniqKey="Ciruela F" first="Francisco" last="Ciruela">Francisco Ciruela</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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